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Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells

TRA-8, a monoclonal antibody to death receptor 5 induces apoptosis in various cancer cells; however the degree of sensitivity varies from highly sensitive to resistant. We have previously shown resistance to TRA-8 can be reversed using chemotherapeutic agents, but the mechanism underlying this sensi...

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מידע ביבליוגרפי
Main Authors: Amm, Hope M., Zhou, Tong, Steg, Adam D., Kuo, Huichien, Li, Yufeng, Buchsbaum, Donald J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086592/
https://ncbi.nlm.nih.gov/pubmed/21357440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0133
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