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The Sphingolipid Degradation Product Trans-2-Hexadecenal Induces Cytoskeletal Reorganization and Apoptosis in a JNK-Dependent Manner
The bioactive signaling molecule D-erythro-sphingosine 1-phosphate (S1P) is irreversibly degraded by the enzyme S1P lyase (SPL). The reaction of SPL with C18-S1P generates ethanolamine phosphate and a long chain fatty aldehyde, trans-2-hexadecenal. Modulation of SPL expression in cells and organisms...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086202/ https://ncbi.nlm.nih.gov/pubmed/21385609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.02.009 |
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