Loading...
Zinc Chelation with Hydroxamate in Histone Deacetylases Modulated by Water Access to the Linker Binding Channel
It is of significant biological interest and medical importance to develop class- and isoform-selective histone deacetylases (HDAC) modulators. The impact of the linker component on HDAC inhibition specificity was revealed, but has not been understood. Herein with Born-Oppenheimer ab initio QM/MM mo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086135/ https://ncbi.nlm.nih.gov/pubmed/21456530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja111104p |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|