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Zinc Chelation with Hydroxamate in Histone Deacetylases Modulated by Water Access to the Linker Binding Channel
It is of significant biological interest and medical importance to develop class- and isoform-selective histone deacetylases (HDAC) modulators. The impact of the linker component on HDAC inhibition specificity was revealed, but has not been understood. Herein with Born-Oppenheimer ab initio QM/MM mo...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086135/ https://ncbi.nlm.nih.gov/pubmed/21456530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja111104p |
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