sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration

Secreted frizzled-related protein (sFRP)-1 is a Wnt antagonist that inhibits breast carcinoma cell motility, whereas the secreted glycoprotein thrombospondin-1 stimulates adhesion and motility of the same cells. We examined whether thrombospondin-1 and sFRP-1 interact directly or indirectly to modul...

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Bibliographische Detailangaben
Hauptverfasser: Martin-Manso, Gema, Calzada, Maria J., Chuman, Yoshiro, Sipes, John M., Xavier, Charles P., Wolf, Vladimir, Kuznetsova, Svetlana A., Rubin, Jeffrey S., Roberts, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085965/
https://ncbi.nlm.nih.gov/pubmed/21402050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.03.004
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