A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and Citrate Buffer

In the current study, the effect of metal ions in combination with buffers (citrate, acetate, pH 4.5) on the stability of aqueous solutions of oxytocin was investigated. Both monovalent metal ions (Na(+) and K(+)) and divalent metal ions (Ca(2+), Mg(2+), and Zn(2+)) were tested all as chloride salts...

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Hlavní autoři: Avanti, Christina, Amorij, Jean-Pierre, Setyaningsih, Dewi, Hawe, Andrea, Jiskoot, Wim, Visser, Jan, Kedrov, Alexej, Driessen, Arnold J. M., Hinrichs, Wouter L. J., Frijlink, Henderik W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085697/
https://ncbi.nlm.nih.gov/pubmed/21448747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9268-7
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