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Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection

Tryptophan catabolism via the kynurenine pathway is dependent on the enzyme Indoleamine 2,3-dioxygenase (IDO). Expression of IDO is upregulated in a number of inflammatory settings such as wounding and infection, and the resulting local tryptophan depletion may inhibit the replication of intracellul...

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Bibliografiske detaljer
Main Authors: BELL, L V, ELSE, K J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084993/
https://ncbi.nlm.nih.gov/pubmed/21392042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-3024.2010.01272.x
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