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SPG20 Protein Spartin Associates with Cardiolipin via Its Plant-Related Senescence Domain and Regulates Mitochondrial Ca(2+) Homeostasis

Hereditary spastic paraplegias (HSPs) are a group of neurological disorders characterized clinically by spasticity of lower limbs and pathologically by degeneration of the corticospinal tract. Troyer syndrome is an autosomal recessive HSP caused by a frameshift mutation in the spartin (SPG20) gene....

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Detalhes bibliográficos
Main Authors: Joshi, Dinesh C., Bakowska, Joanna C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084803/
https://ncbi.nlm.nih.gov/pubmed/21559443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019290
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