The Human Splice Variant Δ16HER2 Induces Rapid Tumor Onset in a Reporter Transgenic Mouse

Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a HER2 splice variant lacking exon-16 (Δ16HER2) has been detected in human breast carcinomas. This alternative protein, a normal byproduct of HER2, has an incr...

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Hlavní autoři: Marchini, Cristina, Gabrielli, Federico, Iezzi, Manuela, Zenobi, Santa, Montani, Maura, Pietrella, Lucia, Kalogris, Cristina, Rossini, Anna, Ciravolo, Valentina, Castagnoli, Lorenzo, Tagliabue, Elda, Pupa, Serenella M., Musiani, Piero, Monaci, Paolo, Menard, Sylvie, Amici, Augusto
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084693/
https://ncbi.nlm.nih.gov/pubmed/21559085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018727
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