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Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

Epidermal growth factor receptor (EGFR)-mediated signaling helps regulate bone development and healing through its effects on osteogenic cells. Here, we show how EGFR activity and osteogenic differentiation responses in primary human bone marrow-derived multipotent stromal cells (MSCs) are influence...

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Detalhes bibliográficos
Main Authors: Platt, Manu O., Roman, Arian J., Wells, Alan, Lauffenburger, Douglas A., Griffith, Linda G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084602/
https://ncbi.nlm.nih.gov/pubmed/19544388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21854
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