Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits

Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information...

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Detalhes bibliográficos
Main Authors: Niwa, Minae, Kamiya, Atsushi, Murai, Rina, Kubo, Ken-ichiro, Gruber, Aaron J, Tomita, Kenji, Lu, Lingling, Tomisato, Shuta, Jaaro-Peled, Hanna, Seshadri, Saurav, Hiyama, Hideki, Huang, Beverly, Kohda, Kazuhisa, Noda, Yukihiro, O’Donnell, Patricio, Nakajima, Kazunori, Sawa, Akira, Nabeshima, Toshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084528/
https://ncbi.nlm.nih.gov/pubmed/20188653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.01.019
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