FLIM FRET Technology for Drug Discovery: Automated Multiwell-Plate High-Content Analysis, Multiplexed Readouts and Application in Situ**

A fluorescence lifetime imaging (FLIM) technology platform intended to read out changes in Förster resonance energy transfer (FRET) efficiency is presented for the study of protein interactions across the drug-discovery pipeline. FLIM provides a robust, inherently ratiometric imaging modality for dr...

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Detalhes bibliográficos
Principais autores: Kumar, Sunil, Alibhai, Dominic, Margineanu, Anca, Laine, Romain, Kennedy, Gordon, McGinty, James, Warren, Sean, Kelly, Douglas, Alexandrov, Yuriy, Munro, Ian, Talbot, Clifford, Stuckey, Daniel W, Kimberly, Christopher, Viellerobe, Bertrand, Lacombe, Francois, Lam, Eric W-F, Taylor, Harriet, Dallman, Margaret J, Stamp, Gordon, Murray, Edward J, Stuhmeier, Frank, Sardini, Alessandro, Katan, Matilda, Elson, Daniel S, Neil, Mark A A, Dunsby, Chris, French, Paul M W
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084521/
https://ncbi.nlm.nih.gov/pubmed/21337485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cphc.201000874
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