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Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands

Reported biological activities of Stemona natural products, such as antitussive activity, inspired the development of synthetic methods to access several alkaloids within this family and in so doing develop a general route to the core skeleta shared by the class of natural products. The chemistry wa...

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Autors principals: Frankowski, Kevin J., Setola, Vincent, Evans, Jon M., Neuenswander, Ben, Roth, Bryan L., Aubé, Jeffrey
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084131/
https://ncbi.nlm.nih.gov/pubmed/21368188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016558108
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