Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

The search for novel therapeutic interventions for viral disease is a challenging pursuit, hallmarked by the paucity of antiviral agents currently prescribed. Targeting of viral proteins has the inextricable challenge of rise of resistance. Safe and effective vaccines are not possible for many viral...

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Main Authors: Bonavia, Aurelio, Franti, Michael, Pusateri Keaney, Erin, Kuhen, Kelli, Seepersaud, Mohindra, Radetich, Branko, Shao, Jian, Honda, Ayako, Dewhurst, Janetta, Balabanis, Kara, Monroe, James, Wolff, Karen, Osborne, Colin, Lanieri, Leanne, Hoffmaster, Keith, Amin, Jakal, Markovits, Judit, Broome, Michelle, Skuba, Elizabeth, Cornella-Taracido, Ivan, Joberty, Gerard, Bouwmeester, Tewis, Hamann, Lawrence, Tallarico, John A., Tommasi, Ruben, Compton, Teresa, Bushell, Simon M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084118/
https://ncbi.nlm.nih.gov/pubmed/21502533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017142108
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