Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

Abl interactor 1 (Abi1) plays a critical function in actin cytoskeleton dynamics through participation in the WAVE2 complex. To gain a better understanding of the specific role of Abi1, we generated a conditional Abi1-KO mouse model and MEFs lacking Abi1 expression. Abi1-KO cells displayed defective...

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Detalhes bibliográficos
Main Authors: Dubielecka, Patrycja M., Ladwein, Kathrin I., Xiong, Xiaoling, Migeotte, Isabelle, Chorzalska, Anna, Anderson, Kathryn V., Sawicki, Janet A., Rottner, Klemens, Stradal, Theresia E., Kotula, Leszek
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084068/
https://ncbi.nlm.nih.gov/pubmed/21482783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016811108
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