Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

In Biology Oriented Synthesis the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is met by the structurally complex scaffolds of natural products (NPs) selected in evolution. The synthesis of NP-inspir...

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Main Authors: Basu, Sudipta, Ellinger, Bernhard, Rizzo, Stefano, Deraeve, Céline, Schürmann, Markus, Preut, Hans, Arndt, Hans-Dieter, Waldmann, Herbert
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084053/
https://ncbi.nlm.nih.gov/pubmed/21415367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015269108
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