Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

In Biology Oriented Synthesis the scaffolds of biologically relevant compound classes inspire the synthesis of focused compound collections enriched in bioactivity. This criterion is met by the structurally complex scaffolds of natural products (NPs) selected in evolution. The synthesis of NP-inspir...

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Detalhes bibliográficos
Main Authors: Basu, Sudipta, Ellinger, Bernhard, Rizzo, Stefano, Deraeve, Céline, Schürmann, Markus, Preut, Hans, Arndt, Hans-Dieter, Waldmann, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084053/
https://ncbi.nlm.nih.gov/pubmed/21415367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015269108
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