Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome

Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 by activated protein kinase C. In contrast, gen...

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Hauptverfasser: Finch, Andrew J., Hilcenko, Christine, Basse, Nicolas, Drynan, Lesley F., Goyenechea, Beatriz, Menne, Tobias F., González Fernández, África, Simpson, Paul, D'Santos, Clive S., Arends, Mark J., Donadieu, Jean, Bellanné-Chantelot, Christine, Costanzo, Michael, Boone, Charles, McKenzie, Andrew N., Freund, Stefan M.V., Warren, Alan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084026/
https://ncbi.nlm.nih.gov/pubmed/21536732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.623011
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