A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.

The c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that recognize purine-rich motifs. The v-ets oncogene of the avian retrovirus E26 differs from its cellular progenitor p68c-ets-1 by two amino acid substitutions (alanine 285 and isoleucine 445 in c-ets-1 both substituted...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Soudant, N, Albagli, O, Dhordain, P, Flourens, A, Stéhelin, D, Leprince, D
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC308383/
https://ncbi.nlm.nih.gov/pubmed/7937106
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