MMP-1 drives immunopathology in human tuberculosis and transgenic mice

Mycobacterium tuberculosis can cause lung tissue damage to spread, but the mechanisms driving this immunopathology are poorly understood. The breakdown of lung matrix involves MMPs, which have a unique ability to degrade fibrillar collagens at neutral pH. To determine whether MMPs play a role in the...

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Detalhes bibliográficos
Main Authors: Elkington, Paul, Shiomi, Takayuki, Breen, Ronan, Nuttall, Robert K., Ugarte-Gil, Cesar Augusto, Walker, Naomi F., Saraiva, Luísa, Pedersen, Bernadette, Mauri, Francesco, Lipman, Marc, Edwards, Dylan R., Robertson, Brian D., D’Armiento, Jeanine, Friedland, Jon S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083790/
https://ncbi.nlm.nih.gov/pubmed/21519144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45666
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