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Mitochondrial Ca(2+) and ROS take center stage to orchestrate TNF-α–mediated inflammatory responses
Proinflammatory stimuli induce inflammation that may progress to sepsis or chronic inflammatory disease. The cytokine TNF-α is an important endotoxin-induced inflammatory glycoprotein produced predominantly by macrophages and lymphocytes. TNF-α plays a major role in initiating signaling pathways and...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083786/ https://ncbi.nlm.nih.gov/pubmed/21519140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57748 |
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