Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex

Mammalian lipid homeostasis requires proteolytic activation of membrane-bound sterol regulatory element binding protein (SREBP) transcription factors through sequential action of the Golgi Site-1 and Site-2 proteases. Here, we report that while SREBP function is conserved in fungi, fission yeast emp...

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Detalhes bibliográficos
Main Authors: Stewart, Emerson V., Nwosu, Christine C., Tong, Zongtian, Roguev, Assen, Cummins, Timothy D., Kim, Dong-Uk, Hayles, Jacqueline, Park, Han-Oh, Hoe, Kwang-Lae, Powell, David W., Krogan, Nevan J., Espenshade, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083633/
https://ncbi.nlm.nih.gov/pubmed/21504829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.035
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