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The Hepatocarcinogenic Effect of Methionine and Choline Deficient Diets: an Adaptation to the Warburg Effect?
Normal differentiated hepatocytes primarily metabolize methionine, via homocysteine synthesis, through the transsulfuration pathway. In addition to glutathione, this pathway produces α-ketobutyrate that is further metabolized in the mitochondria. It is only under low methionine conditions that diffe...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083460/ https://ncbi.nlm.nih.gov/pubmed/21284672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2010.01404.x |
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