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Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). The smallest of these is sunflower trypsin inhibitor (SFTI-1), a potent and broad-range protease inhibitor. Recently, we re-engi...

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Detalhes bibliográficos
Main Authors: Swedberg, Joakim E., de Veer, Simon J., Sit, Kei C., Reboul, Cyril F., Buckle, Ashley M., Harris, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083445/
https://ncbi.nlm.nih.gov/pubmed/21556330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019302
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