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Using Functional Annotation for the Empirical Determination of Bayes Factors for Genome-Wide Association Study Analysis

A genome wide association study (GWAS) typically results in a few highly significant ‘hits’ and a much larger set of suggestive signals (‘near-hits’). The latter group are expected to be a mixture of true and false associations. One promising strategy to help separate these is to use functional anno...

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Detalhes bibliográficos
Main Authors: Knight, Jo, Barnes, Michael R., Breen, Gerome, Weale, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083387/
https://ncbi.nlm.nih.gov/pubmed/21556132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014808
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