Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

Parkinson disease is caused by the death of midbrain dopamine neurons from oxidative stress, abnormal protein aggregation, and genetic predisposition. In 2003, Bonifati et al. (23) found that a single amino acid mutation in the DJ-1 protein was associated with early-onset, autosomal recessive Parkin...

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Detalhes bibliográficos
Main Authors: Zhou, Wenbo, Bercury, Kathryn, Cummiskey, Jessica, Luong, Nancy, Lebin, Jacob, Freed, Curt R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083206/
https://ncbi.nlm.nih.gov/pubmed/21372141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211029
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