Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein

Retroviruses require both spliced and unspliced RNAs for replication. Accumulation of Rous Sarcoma virus (RSV) unspliced RNA depends upon the negative regulator of splicing (NRS). Its 5′-part is considered as an ESE binding SR proteins. Its 3′-part contains a decoy 5′-splice site (ss), which inhibit...

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Main Authors: Bar, Aileen, Marchand, Virginie, Khoury, Georges, Dreumont, Natacha, Mougin, Annie, Robas, Nathalie, Stévenin, James, Visvikis, Athanase, Branlant, Christiane
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082916/
https://ncbi.nlm.nih.gov/pubmed/21183462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1114
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