A Yeast Model of FUS/TLS-Dependent Cytotoxicity

FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected s...

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Detalhes bibliográficos
Main Authors: Ju, Shulin, Tardiff, Daniel F., Han, Haesun, Divya, Kanneganti, Zhong, Quan, Maquat, Lynne E., Bosco, Daryl A., Hayward, Lawrence J., Brown, Robert H., Lindquist, Susan, Ringe, Dagmar, Petsko, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082520/
https://ncbi.nlm.nih.gov/pubmed/21541368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001052
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