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The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver
UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of drugs, chemicals, and hormones. The development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples using bilirubin, serotonin activity assays, and Western blot as well as pharmacokinetic scaling. UGT activi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082376/ https://ncbi.nlm.nih.gov/pubmed/21266593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037192 |
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