Impaired β-adrenergic responsiveness accentuates dysfunctional excitation–contraction coupling in an ovine model of tachypacing-induced heart failure

ABSTRACT: Reduced inotropic responsiveness is characteristic of heart failure (HF). This study determined the cellular Ca(2+) homeostatic and molecular mechanisms causing the blunted β-adrenergic (β-AR) response in HF. We induced HF by tachypacing in sheep; intracellular Ca(2+) concentration was mea...

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Detalhes bibliográficos
Main Authors: Briston, Sarah J, Caldwell, Jessica L, Horn, Margaux A, Clarke, Jessica D, Richards, Mark A, Greensmith, David J, Graham, Helen K, Hall, Mark C S, Eisner, David A, Dibb, Katharine M, Trafford, Andrew W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082097/
https://ncbi.nlm.nih.gov/pubmed/21242250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.203984
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