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Functional analysis of the conserved hydrophobic gate region of the magnesium transporter CorA
The Leu294 residue in the cytoplasmic neck of Thermotoga maritima CorA is considered to be the main gate for Mg(2+) transport. We created three site-directed mutants at this position: in the Leu294Asp and Leu294Gly mutants we observed a defect in closing of the pore, while in the Leu294Arg mutant no...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier Pub. Co
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3082049/ https://ncbi.nlm.nih.gov/pubmed/21074514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.10.017 |
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