Evidence of mechanism how rs7575840 influences apolipoprotein B containing lipid particles

OBJECTIVE: Recent genome-wide association studies (GWAS) identified a variant rs7575840 in the apolipoprotein B (APOB) gene region to be associated with LDL-C. However, the underlying functional mechanism of this variant that resides 6.5 kb upstream of APOB has remained unknown. Our objective was to...

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Bibliografiset tiedot
Päätekijät: Haas, Blake E., Weissglas-Volkov, Daphna, Aguilar-Salinas, Carlos A., Nikkola, Elina, Vergnes, Laurent, Cruz-Bautista, Ivette, Riba, Laura, Stancakova, Alena, Kuusisto, Johanna, Soininen, Pasi, Kangas, Antti J., Ala-Korpela, Mika, Tusie-Luna, Teresa, Laakso, Markku, Pajukanta, Päivi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081410/
https://ncbi.nlm.nih.gov/pubmed/21393584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.224139
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