Bortezomib Stabilizes Mitotic Cyclins and Prevents Cell Cycle Progression via Inhibition of UBE2C in Colorectal Carcinoma

Substantial evidence implicates the ubiquitin-conjugating enzyme E2C (UBE2C) gene, in several human cancers, including colorectal carcinoma (CRC). We therefore investigated the prognostic value of UBE2C alterations in CRC and UBE2C signaling in CRC cell lines. UBE2C protein expression and UBE2C gene...

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Main Authors: Bavi, Prashant, Uddin, Shahab, Ahmed, Maqbool, Jehan, Zeenath, Bu, Rong, Abubaker, Jehad, Sultana, Mehar, Al-Sanea, Nasser, Abduljabbar, Alaa, Ashari, Luai H., Alhomoud, Samar, Al-Dayel, Fouad, Prabhakaran, Sarita, Hussain, Azhar R., Al-Kuraya, Khawla S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081207/
https://ncbi.nlm.nih.gov/pubmed/21514426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.034
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