Increased Expression of Wild-Type or a Centronuclear Myopathy Mutant of Dynamin 2 in Skeletal Muscle of Adult Mice Leads to Structural Defects and Muscle Weakness

Dynamin 2 (DNM2) is a large GTPase implicated in many cellular functions, including cytoskeleton regulation and endocytosis. Although ubiquitously expressed, DNM2 was found mutated in two genetic disorders affecting different tissues: autosomal dominant centronuclear myopathy (ADCNM; skeletal muscle...

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Hlavní autoři: Cowling, Belinda S., Toussaint, Anne, Amoasii, Leonela, Koebel, Pascale, Ferry, Arnaud, Davignon, Laurianne, Nishino, Ichizo, Mandel, Jean-Louis, Laporte, Jocelyn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081151/
https://ncbi.nlm.nih.gov/pubmed/21514436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.054
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