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Formation of DNA triple helices incorporating blocks of G.GC and T.AT triplets using short acridine-linked oligonucleotides.
We have used DNase I footprinting to assess triple helix formation at target sites containing the sequences A6G6.C6T6 and G6A6.T6C6. These sequences can be recognized by the acridine-linked oligopyrimidines Acr-T5C5 and Acr-C5T5 respectively at low pH, using well-characterised T.AT and C+.GC triplet...
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| Main Author: | |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1994
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC308115/ https://ncbi.nlm.nih.gov/pubmed/8029007 |
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