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Downregulation of PTEN at Corneal Wound Sites Accelerates Wound Healing through Increased Cell Migration
PURPOSE. The PI3K/Akt pathway is required for cell polarization and migration, whereas the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has inhibitory effects on the PI3K/Akt pathway. The authors therefore hypothesized that wounding would downregulate PTEN and that this downregul...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080732/ https://ncbi.nlm.nih.gov/pubmed/21212174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5972 |
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