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Effect of template secondary structure on the inhibition of HIV-1 reverse transcriptase by a pyridinone non-nucleoside inhibitor.

The importance of RNA secondary structure on HIV-1 reverse transcriptase catalyzed polymerization and on the potency of the pyridin-2-one inhibitor 3-(4,7-dichlorobenzoxazol-2-ylmethylamino)-5-ethyl-6-meth ylpyridin-2(1H)-one, L-697,661, were investigated by employing heteromeric primer-template sys...

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Udgivet i:Nucleic Acids Res
Principais autores: Olsen, D B, Carroll, S S, Culberson, J C, Shafer, J A, Kuo, L C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1994
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308002/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7514786/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.8.1437
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