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Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously

Arginase (EC 3.5.3.1) is an aminohydrolase that acts on l-arginine to produce urea and ornithine. Two isotypes of the enzyme are found in humans. Type I is predominantly produced in the liver and is a homotrimer of 35 kDa subunits. Human arginase (hArginase) I is seen to be up-regulated in many dise...

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Detalhes bibliográficos
Main Authors: Newman, Janet, Pearce, Lesley, Lesburg, Charles A., Strickland, Corey, Peat, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079981/
https://ncbi.nlm.nih.gov/pubmed/21206033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110046208
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