The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA.
The modified base, 5-methylcytosine, constitutes approximately 1% of human DNA, but sites containing 5-methylcytosine account for at least 30% of all germline and somatic point mutations. A genetic assay with a sensitivity of 1 in 10(7), based on reversion to neomycin resistance of a mutant pSV2-neo...
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| Gepubliceerd in: | Nucleic Acids Res |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
1994
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| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8152929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.6.972 |
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