ATP release due to Thy-1–integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation

Thy-1, an abundant mammalian glycoprotein, interacts with αvβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to the extracellular matrix. The signaling cascade includes calcium-dependent act...

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Détails bibliographiques
Auteurs principaux: Henríquez, Mauricio, Herrera-Molina, Rodrigo, Valdivia, Alejandra, Alvarez, Alvaro, Kong, Milene, Muñoz, Nicolás, Eisner, Verónica, Jaimovich, Enrique, Schneider, Pascal, Quest, Andrew F. G., Leyton, Lisette
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2011
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078821/
https://ncbi.nlm.nih.gov/pubmed/21502139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.073171
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