Intraocular Pharmacokinetics of a Crystalline Lipid Prodrug, Octadecyloxyethyl-Cyclic-Cidofovir, for Cytomegalovirus Retinitis

PURPOSE: To evaluate the intraocular pharmacokinetics of octadecyloxyethyl-cyclic-cidofovir (ODE-cCDV) after intravitreal injection into rabbit eyes. METHODS: Twenty-seven New Zealand red rabbits (27 eyes) received intravitreal injections of (14)C-labeled ODE-cCDV (100 μg drug suspended in 5% dextro...

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Autors principals: Cheng, Lingyun, Beadle, James R., Tammewar, Ajay, Hostetler, Karl Y., Hoh, Carl, Freeman, William R.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2011
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078534/
https://ncbi.nlm.nih.gov/pubmed/21351867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2010.0155
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