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PGC-1α Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice
Chronic heart failure often results in catabolic muscle wasting, exercise intolerance, and death. Oxidative muscles, which have greater expression of the metabolic master gene peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) and its target genes, are more resistant to catabolic w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Investigative Pathology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078433/ https://ncbi.nlm.nih.gov/pubmed/21435455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.005 |
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