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A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

It is proposed that a progressive series of mutations and epigenetic events leads to human colorectal cancer (CRC) and metastasis. Furthermore, data from resequencing of the coding regions of human CRC suggests that a relatively large number of mutations occur in individual human CRC, most at low fr...

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Detalhes bibliográficos
Main Authors: Starr, Timothy K., Scott, Patricia M., Marsh, Benjamin M., Zhao, Lei, Than, Bich L. N., O'Sullivan, M. Gerard, Sarver, Aaron L., Dupuy, Adam J., Largaespada, David A., Cormier, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078351/
https://ncbi.nlm.nih.gov/pubmed/21436051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018012108
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