Structural and Functional Analysis of Tomosyn Identifies Domains Important in Exocytotic Regulation

Tomosyn is a 130-kDa cytosolic R-SNARE protein that associates with Q-SNAREs and reduces exocytotic activity. Two paralogous genes, tomosyn-1 and -2, occur in mammals and produce seven different isoforms via alternative splicing. Here, we map the structural differences between the yeast homologue of...

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Autors principals: Williams, Antionette L., Bielopolski, Noa, Meroz, Daphna, Lam, Alice D., Passmore, Daniel R., Ben-Tal, Nir, Ernst, Stephen A., Ashery, Uri, Stuenkel, Edward L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077652/
https://ncbi.nlm.nih.gov/pubmed/21330375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.215624
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