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Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis.
The unusually high frequency of misincorporation by HIV-1 reverse transcriptase (HIV RT) is likely to be the major factor in the rapid accumulation of viral mutations in AIDS, especially in the env gene. To investigate the ability of HIV RT to copy the env gene, we subcloned an HIV env gene fragment...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1994
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307744/ https://ncbi.nlm.nih.gov/pubmed/7510388 |
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