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Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer

We have created a transgenic mouse with tissue-specific expression of the human papilloma virus (HPV) 16 E6 and E7 oncoproteins in the thyroid as a model of HPV transformed cancer. The expression of the transgenes results in the formation of palpable thyroid tumors. E7 is not expressed in other tiss...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Souders, Nicholas C., Sewell, Duane A., Pan, Zhen-Kun, Hussain, S. Farzana, Rodriguez, Alexander, Wallecha, Anu, Paterson, Yvonne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academy of Cancer Immunology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077294/
https://ncbi.nlm.nih.gov/pubmed/17279610
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