Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations

We examined candidate polymorphisms in genes involved in the folate-mediated, one-carbon metabolism pathway, DNMT1 1311V, MTHFD1 R134K and R653Q, MTHFR R594Q, MTR D919G, MTRR H595Y and I22M, SHMT1 L474F, SLC19A1 H27R, and TDG G199S, and associations with rectal tumor characteristics. We hypothesized...

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Detalhes bibliográficos
Main Authors: Curtin, Karen, Ulrich, Cornelia M, Samowitz, Wade S, Wolff, Roger K, Duggan, David J, Makar, Karen W, Caan, Bette J, Slattery, Martha L
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077233/
https://ncbi.nlm.nih.gov/pubmed/21537397
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