ALTERED TGF-ϐ SIGNALING IN A SUB-POPULATION OF HUMAN STROMAL CELLS PROMOTES PROSTATIC CARCINOGENESIS

Carcinoma-associated fibroblasts (CAFs) play a critical role in malignant progression. Loss of TGF-ϐ receptor II (TGFϐR2) in the prostate stroma is correlated with prostatic tumorigenesis. To determine the mechanisms by which stromal heterogeneity due to loss of TGFϐR2 might contribute to cancer pro...

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Autori principali: Franco, Omar E, Jiang, Ming, Strand, Douglas W, Peacock, James, Fernandez, Suzanne, Jackson, Roger S, Revelo, Monica P, Bhowmick, Neil A, Hayward, Simon W
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076790/
https://ncbi.nlm.nih.gov/pubmed/21303979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3142
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