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Impact of Arsenic/Phosphorous substitution on the intrinsic conformational properties of the phosphodiester backbone of DNA investigated using ab initio quantum mechanical calculations

Deoxyribonucleic acid (DNA) is composed of five major elements carbon, hydrogen, nitrogen, oxygen, and phosphorus. The substitution of any of these elements in DNA would be anticipated to have major biological implications. However, recent studies have suggested that the substitution of arsenic into...

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Hlavní autoři: Denning, Elizabeth J., MacKerell, Alexander D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076535/
https://ncbi.nlm.nih.gov/pubmed/21443192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201213b
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