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Structural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled β-lactamase
BACKGROUND: β-lactamase conjugated with environment-sensitive fluorescein molecule to residue 166 on the Ω-loop near its catalytic site is a highly effective biosensor for β-lactam antibiotics. Yet the molecular mechanism of such fluorescence-based biosensing is not well understood. RESULTS: Here we...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076226/ https://ncbi.nlm.nih.gov/pubmed/21443768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-11-15 |
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