Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells

In the transforming growth factor β (TGF-β) superfamily, activin A, TGF-β1, and bone morphogenic protein 4 (BMP-4) have various effects on hematopoiesis, including early mesodermo-hematogenesis. After these cytokines bind to their respective receptor, a regulatory Smad is phosphorylated and becomes...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chiba, Shigeru, Takeshita, Kenichi, Imai, Yoichi, Kumano, Keiki, Kurokawa, Mineo, Masuda, Shigeo, Shimizu, Kiyoshi, Nakamura, Shuji, Ruddle, Frank H., Hirai, Hisamaru
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307610/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14671321/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536757100
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