Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells

In the transforming growth factor β (TGF-β) superfamily, activin A, TGF-β1, and bone morphogenic protein 4 (BMP-4) have various effects on hematopoiesis, including early mesodermo-hematogenesis. After these cytokines bind to their respective receptor, a regulatory Smad is phosphorylated and becomes...

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Bibliografiske detaljer
Main Authors: Chiba, Shigeru, Takeshita, Kenichi, Imai, Yoichi, Kumano, Keiki, Kurokawa, Mineo, Masuda, Shigeo, Shimizu, Kiyoshi, Nakamura, Shuji, Ruddle, Frank H., Hirai, Hisamaru
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307610/
https://ncbi.nlm.nih.gov/pubmed/14671321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536757100
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