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Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases

Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to b...

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Bibliographic Details
Main Authors: Chen, Dawei, Vollmar, Melanie, Rossi, Marianna N., Phillips, Claire, Kraehenbuehl, Rolf, Slade, Dea, Mehrotra, Pawan V., von Delft, Frank, Crosthwaite, Susan K., Gileadi, Opher, Denu, John M., Ahel, Ivan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075673/
https://ncbi.nlm.nih.gov/pubmed/21257746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.206771
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